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Apart from the PC1 and PC2 transmembrane proteins, a series of cell surface receptors can contribute to increased cAMP and proliferation, including vasopressin receptor (V2R) and Wnt receptors depicted in Figure 3, and discussed in section 3.1.1 and 3.1.3., respectively

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The functioning of this system is based on the interaction of ligands (including endogenous endocannabinoids, e.g., anandamide, but also exogenous plant derivatives - phytocannabinoids) with specific endocannabinoid receptors, CB1/2